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The validity of a set of computed beam weights WJ may be checked using a real beam and measuring the resulting dose distribution along the central ray. Figure 27 shows a set of Bragg ionization curves with the appropriate beam weights applied and their sum. Figure 29 shows the calculated and measured fractional survivals as a function of depth for 3% survival after one irradiation in the region of the spread-out Bragg ionization curve. A different biological
endpoint, such as a different survival fraction or a fractionation scheme, gives a different set of beam weights, and therefore, a different slope in the SOBP dose.