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Fractures are by far the most frequent abnormality of
the skeletal system (5), and they occur with decreases in
bone strength. This weakness is due largely to a reduction
in bone mass caused by an uncoupling of bone formation
and resorption. In pharmacological and pathophysiological studies of bone disorders using experimental animals,
determination of bone status is usually confined to histological evaluation and/or measurement of bone density
and its composition, dry weight, bone ash or mineral content. Recently, to gain a better understanding of the structural stability and resistance to bone fracture, the
quality
of bone has been assessed by measurements of stiffness,
strength, toughness and ductility in rat femora.